Max Costa Selected Research

Nose Neoplasms

12/2013	Plasma Anti-Glycan Antibody Profiles Associated with Nickel level in Urine.
10/2013	Nickel and epigenetic gene silencing.
2/2013	Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects.
2/2012	Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel.
3/2011	Effects of nickel treatment on H3K4 trimethylation and gene expression.
12/2005	Nickel carcinogenesis: epigenetics and hypoxia signaling.

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Max Costa Research Topics

Disease

62	Carcinogenesis 11/2021 - 06/2002
62	Neoplasms (Cancer) 11/2021 - 10/2002
32	Hypoxia (Hypoxemia) 05/2014 - 03/2002
14	Lung Neoplasms (Lung Cancer) 11/2021 - 04/2003
7	Inflammation (Inflammations) 11/2021 - 01/2013
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 02/2009
7	Carcinoma (Carcinomatosis) 05/2010 - 06/2006
6	Nose Neoplasms 12/2013 - 12/2005
4	Genomic Instability 11/2021 - 03/2011
3	Hypertension (High Blood Pressure) 12/2017 - 02/2013
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2017 - 01/2014
2	Kidney Neoplasms (Kidney Cancer) 01/2019 - 10/2002
2	Obesity 11/2015 - 01/2015
2	Hepatocellular Carcinoma (Hepatoma) 11/2015 - 10/2010
2	Atherosclerosis 01/2014 - 09/2010
2	Coronary Disease (Coronary Heart Disease) 02/2013 - 01/2010
2	Adenocarcinoma of Lung 03/2011 - 04/2005
2	Osteosarcoma (Osteogenic Sarcoma) 02/2006 - 01/2004
1	Chemical and Drug Induced Liver Injury 01/2021
1	Heart Failure 01/2021
1	Neoplasm Metastasis (Metastasis) 12/2020
1	Aneuploidy (Aneuploid) 09/2020
1	Foot Diseases 01/2020
1	Chromosome Breakage 04/2019
1	Poisoning 01/2019
1	Acute Promyelocytic Leukemia 01/2018
1	Hyperglycemia 12/2017

Drug/Important Bio-Agent (IBA)

46	NickelIBA 08/2021 - 05/2002
22	ArsenicIBA 01/2021 - 03/2003
19	Histones (Histone)IBA 09/2020 - 06/2002
18	CarcinogensIBA 08/2021 - 04/2003
18	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
13	chromium hexavalent ionIBA 11/2021 - 04/2002
12	MetalsIBA 11/2021 - 10/2002
12	IronIBA 07/2012 - 01/2004
11	Transcription Factors (Transcription Factor)IBA 01/2021 - 03/2002
10	Oxygen (Dioxygen)IBA 07/2016 - 04/2003
9	ChromiumIBA 01/2020 - 06/2007
8	IonsIBA 01/2020 - 10/2002
8	EnzymesIBA 06/2013 - 12/2003
6	Drinking WaterIBA 01/2020 - 05/2004
6	CadmiumIBA 01/2020 - 01/2009
6	CobaltIBA 07/2009 - 01/2004
6	ChromatesIBA 04/2009 - 04/2002
5	arseniteIBA 01/2021 - 02/2006
5	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2019
5	Biological ProductsIBA 12/2020 - 01/2004
5	RNA (Ribonucleic Acid)IBA 10/2020 - 10/2002
5	Messenger RNA (mRNA)IBA 09/2020 - 10/2002
5	Lysine (L-Lysine)FDA Link 12/2010 - 12/2005
5	DNA (Deoxyribonucleic Acid)IBA 09/2008 - 06/2002
4	Carrier Proteins (Binding Protein)IBA 01/2021 - 11/2006
4	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2021 - 03/2002
4	Taurine FDA Link 01/2016 - 01/2010
4	histone H3 trimethyl Lys4IBA 03/2011 - 09/2008
4	Hypoxia-Inducible Factor 1IBA 01/2008 - 03/2002
4	Deferoxamine (Desferal)FDA LinkGeneric 10/2007 - 12/2003
3	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2021 - 11/2005
3	LipidsIBA 01/2021 - 12/2012
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 01/2012
3	Particulate MatterIBA 01/2017 - 01/2014
3	Chelating AgentsIBA 10/2007 - 01/2004
3	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 11/2005 - 07/2003
2	Nuclear Proteins (Protein, Nuclear)IBA 01/2021 - 12/2020
2	BerylliumIBA 01/2020 - 01/2019
2	DNA AdductsIBA 04/2019 - 03/2006
2	SmokeIBA 01/2019 - 04/2003
2	TungstenIBA 01/2018 - 10/2015
2	Small Interfering RNA (siRNA)IBA 01/2016 - 08/2010
2	Bile Acids and Salts (Bile Acids)IBA 01/2016 - 02/2013
2	ORALIT (ORS)IBA 01/2016 - 11/2015
2	AgarIBA 01/2016 - 10/2015
2	nickel chlorideIBA 01/2015 - 06/2007
2	ChromatinIBA 08/2014 - 03/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2010 - 03/2002
2	UbiquitinIBA 01/2010 - 12/2009
2	LuciferasesIBA 10/2007 - 06/2006
2	ElementsIBA 10/2007 - 10/2002
2	Vitamin E FDA LinkGeneric 06/2007 - 05/2002
2	N-myc downstream-regulated gene 1 proteinIBA 05/2007 - 01/2004
2	Glucose (Dextrose)FDA LinkGeneric 11/2006 - 11/2006
2	Ferritins (Ferritin)IBA 11/2006 - 06/2006
2	2-tert-butyl-6-methyl-3-hydroxypyridineIBA 11/2006 - 06/2006
2	Codon (Codons)IBA 03/2006 - 04/2003
2	NF-kappa B (NF-kB)IBA 06/2004 - 10/2002
2	Tumor Biomarkers (Tumor Markers)IBA 07/2003 - 10/2002
2	CalciumIBA 10/2002 - 03/2002
1	PoisonsIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	MethyltransferasesIBA 01/2021
1	Anesthetics (Anesthetic Agents)IBA 01/2021
1	Coal (Coals)IBA 01/2019
1	Nuclear Matrix-Associated ProteinsIBA 01/2018
1	Therapeutic UsesIBA 01/2018
1	AlloysIBA 01/2018
1	A-factor (Streptomyces)IBA 12/2017
1	antineoplaston A10 (A 10)IBA 12/2017
1	Benzo(a)pyreneIBA 12/2017

Therapy/Procedure

8	Therapeutics 01/2021 - 11/2006
2	Drug Therapy (Chemotherapy) 11/2021 - 05/2007